I Cor 1:21-23– For after that in the wisdom of God the world by wisdom knew not God, it pleased God by the foolishness of preaching to save them that believe. 22 For the Jews require a sign, and the Greeks seek after wisdom: 23 But we preach Christ crucified, unto the Jews a stumblingblock, and unto the Greeks foolishness;
This past week I have found myself listening to a lot of skeptics of religion. I was really surprised by one well-known skeptic in particular who is just completely hateful toward Christians. It was really shocking to see the anger and assault he brought on Christianity (which is his favorite topic to rip). This same guy preaches tolerance:)
Unfortunately religion and Christianity are thrown into one pot for most skeptics. They see us as people with a neurological disorder – believing in an imaginary friend. This particular man repeatedly speaks about how “stupid” we are for our beliefs.
In the passage above Paul tells us that the Greeks of his day had a reputation for seeking wisdom just as most men do today. They believed that philosophers were the only truly “wise” people. But the wisdom, which they sought, would never lead them to know God which would seem to be the highest achievement man could attain.
There are many truths in the Bible that run contrary to the wisdom of man. This is on purpose, for God has chosen to “…destroy the wisdom of the wise, and…. bring to nothing the understanding of the prudent.” 
God has made the salvation of man a path of humility, which is too painful a path for prideful man. If one would be saved he will have to come to Jesus who died on a cross for the punishment of that very person’s crimes.
The way of freedom, forgiveness and to live forever in eternal bliss is always going to be foolishness to anyone who stands proudly and stubbornly in his or her own wisdom.
Romans 3:27 – 27 Where is boasting then? It is excluded. By what law? of works? Nay: but by the law of faith. 
True salvation has no room for pride, boasting, or the wisdom of man. It is of humility, for repentant sinners, who see their desperation for a gift from God.
God in His wisdom saw that we as fallen creatures could have nothing to do with our salvation except to believe on the Lord Jesus Christ. That is true yet humbling wisdom!
 The Holy Bible: King James Version. (2009). (Electronic Edition of the 1900 Authorized Version., 1 Co 1:17–23). Bellingham, WA: Logos Research Systems, Inc.
 The Holy Bible: King James Version. (2009). (Electronic Edition of the 1900 Authorized Version., 1 Co 1:19). Bellingham, WA: Logos Research Systems, Inc.
 The Holy Bible: King James Version. (2009). (Electronic Edition of the 1900 Authorized Version., Ro 3:27). Bellingham, WA: Logos Research Systems, Inc.